Endocrine Abstracts

In the human adrenal cortex, three mitochondrial cytochromes P450 are involved in steroid hormone biosynthesis. CYP11A1 catalyses side-chain cleavage of cholesterol to yield pregnenolone, whereas P45011B1 is responsible for the conversion of 11-deoxycorticosterone and 11-deoxycortisol to the glucocorticoids, corticosterone and cortisol, respectively. The aldosterone synthase (CYP11B2) catalyses the 11β-hydroxylation, 18-hydroxylation and 18-oxidation of deoxycorticosteron...